We offer target selection/evaluation, drug design and early stage development to research organizations interested in strategic partnerships or services. 

Small molecule drug design services are validated across diverse drug target classes, with specialization for small molecules targeting RNA/protein complexes and multimodal targets. 

Screening services are target agnostic. 

Automated high throughput microinjection hardware is in development to facilitate reproducible morphants, xenografts, biologic/LPN screening and live immunofluorescence

 Appropriate for zebrafish, other small animals and bioprinted constructs. High throughput (up to one object/min) liquid handling from 96-well plates with automated  cellular precision positioning and  imaging.  Compatible with calcium imaging and automated laser ablation studies.

Custom disease/reporter model design available, including transgenesis. 

Established models include

1. PK/PD
2. Angiogenesis
3. Ablative brain/spine injury and stroke models
4. Tumorigenic (NF1) with individual tumor tracking
5. Neuroplasticity  (including DAT, PET1 and GLUT subtypes)
6. Neuroactivity (including subtypes and hyperactivity models).                                                                           Suitable for agonist/re-uptake inhibitor differentiation 
7. Cardiovascular profiling (including edema, arrhythmia and hypertension)

Displayed here for angiogenesis (kdrl:GFP),  distribution estimations are possible to visualize

 and quantify autonomously, in vivo and in real time 

Quantification validated with precision MALDI-imaging

Post hoc 3D quantification of compartmental drug penetrance up to single cell precision

Metabolism, peak plasma concentration, time to reach it, total drug exposure over time, half-life, and rate of elimination  also available

NF1 knock-outs are tumorigenic, spontaneously generating aggressive glioblastomas

Tumor GFP expression allows automated multiplex computer vision identification and tracking of progression and angiogenesis for each individual tumor