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Azor Biotek

RNA GUIDed Drug Design

RNA GUIDed Drug DesignRNA GUIDed Drug Design

Azor Biotek is developing RNA-targeting small molecule therapeutics for the safe and curative treatment of neurodegenerative and pulmonary diseases. Our pilot therapeutics are designed to target miR-29 with exquisite specificity and bioavailability dwarfing that of comparable oligonucleotides.

microRNA (miR)

  

miR are inhibitory post-transcriptional regulators. Pathological miR misexpression is often inversely correlated with pathological miR-target-transcript misexpression — as such many miR have been indicated as innately combinational therapeutic drug targets, regulating networks of related misexpressed transcripts. 


6 companies have brought miR-targeting biologics to clinical trial, including a miR-29 oligonucleotide mimic (Remlarsen). The intrinsically poor bioavailability of oligonucleotides has hampered further clinical development.  In contrast, Azor Biotek's miR-29-targeted small molecules are selected for optimized bioavailability and specificity.

Live zebrafish screens

Early screening in zebrafish further selects for therapeutics with high bioavailability, and allow for in vivo quantification of concrete physiological hallmarks while providing approximations of the effective dose, toxicity and off-target effects. 



Indicated Markets

We are developing our miR-29 targeting therapeutics for Parkinson's disease, pulmonary fibrosis (a COVID sequella), and lung cancer.


If a curative therapeutic is developed for Parkinson's it would see widespread adoption, completely disrupting the $7B market and improve patient outcomes of >5% of senior citizens globally. Similarly, a more effective pulmonary fibrosis therapeutic would capture that $5B market, and expand it in proportion with improved prognosis. Other medical conditions indicated for miR-29 have a combined (though less readily addressable) market of >$500B. 


Other miR species have been indicated as targets for a multitude of common conditions, and our platform is not limited to miR — the total potential market for RNA-targeting therapeutics designed with our technology is inconceivably vast. 

2022 Recognitions

PlanIT Competition Winner — Coast Capital Innovation    

CDN Innovation C2C — Global Affairs Canada

BioInnovate Challenge — UvicBiomedical Engineering  

Investor Readiness — Life Science BC  

Invited Speaker — RNA-Targeted Drug Discovery

Invited guest — Worldwide Business with Kathy Ireland

 Top 100 Lifescience Innovators  — YoungStartup Ventures

Non-dilutive financial support for technology innovation 

  Sweet 16 Most Promising Canadian Biotech  — GIIANT PHARMA


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